Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses
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چکیده
منابع مشابه
TLR 2 and TLR 9 contribute to alcohol - mediated liver injury through induction of CXCL 1 1 and neutrophil infiltration
TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 1 and neutrophil infiltration 2 Yoon Seok Roh, Bi Zhang, Rohit Loomba, and Ekihiro Seki 3 Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Los 4 Angeles, California 90048, USA and Division of Gastroenterology, Department of Medicine, 5 University of California, San Diego, Schoo...
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Acute-phase proteins are proteins whose plasma concentrations increase in response to inflammation. The variability in protein plasma levels, and following impact on drug binding extent, cause modifications in the mode of drug action, distribution, disposition and elimination. One of the most important acute phase proteins is a1-acid glycoprotein (AAG or AGP), principal binding protein for basi...
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The immune system is essential to maintain homeostasis with resident microbial populations, ensuring that the symbiotic host-microbial relationship is maintained. In parallel, commensal microbes significantly shape mammalian immunity at the host mucosal surface, as well as systemically. Candida albicans is an opportunistic pathogen that lives as a commensal on skin and mucosa of healthy individ...
متن کاملبررسی تأثیر ابتلا به پریودنتیت مزمن بر میزان بیان ژن TLR-2 و TLR-4 در بافت لثه ای
مقدمه: در عفونتهای پریودنتال پیش نیاز شروع پاسخهای میزبان، شناخت پاتوژنها توسط سیستم ایمنی میزبان میباشد. خانواده رسپتورهای Toll-like (TLRs)، مسئول شناسایی ساختارهای حفظ شده میکروبیال نظیر لیپوپلی ساکارید (LPS) باکتریها میباشند و مسیرهای سیگنال دهنده را که در نهایت منجر به پاسخهای ایمنی میشود، فعال میکنند. هدف از مطالعة حاضر، ارزیابی مقایسه میزان بروز TLR-2 و TLR-4 توسط تکنیک Real-...
متن کاملIncreased α1-3 fucosylation of α-1-acid glycoprotein (AGP) in pancreatic cancer.
Pancreatic cancer (PDAC) lacks reliable diagnostic biomarkers and the search for new biomarkers represents an important challenge. Previous results looking at a small cohort of patients showed an increase in α-1-acid glycoprotein (AGP) fucosylation in advanced PDAC using N-glycan sequencing. Here, we have analysed AGP glycoforms in a larger cohort using several analytical techniques including m...
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ژورنال
عنوان ژورنال: Immunobiology
سال: 2019
ISSN: 0171-2985
DOI: 10.1016/j.imbio.2019.06.003